OMNT article selection
This trimester’s selection is pretty short (sorry, I’m in a rush to finish several research projects). I pointed out a contribution of Jordan Gerton’s team in Optics Express :
http://www.opticsinfobase.org/abstract.cfm?URI=oe-16-9-6183
The papers points out a nice theoretical and experimental study on the limits of single-molecule fluorescence detection within a dense ensemble, using tip-enhanced near-field microscopy. Specifically, the minimum magnitude of tip-induced signal enhancement is discussed and compared to the capabilities of commercially available silicon tips. Last, the authors show that modulation of fluorescence signals induced by an oscillating tip followed by demodulation with a lock-in amplifier increases image contrast by nearly two orders of magnitude.
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