Articles récents

JMC12 : nanophotonics nano-symposium

19 Mars 2010 , Rédigé par JW Publié dans #Nanophotonics pick

During the next national conference on condensed matter, I will be co-organizer of a "mini-colloque" devoted to nano-optics.

See the conference webpage, and the mini-colloque n°8.

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Over 10,000 visits !

15 Février 2010 , Rédigé par JW Publié dans #Fancy lab

During its three-years existence, this blog has received over 10,000 visits, more than 26,000 pages have been viewed. I'm not sure that anybody got an answer to his/her questions;  at least, people reading this blog will get some idea about what I spend my time on... Thanks for passing by !

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Latest (review) paper : nanophotonics and FCS

10 Février 2010 , Rédigé par JW Publié dans #Recent research work

Published in the January issue of Int. J. Mol. Sci., this review is freely available for download here (4.1Mb).

Abstract: Recent advances in nanophotonics open the way for promising applications towards efficient single molecule fluorescence analysis. In this review, we discuss how photonic methods bring innovative solutions for two essential questions: how to detect a single molecule in a highly concentrated solution, and how to enhance the faint optical signal emitted per molecule? The focus is set primarily on the widely used technique of fluorescence correlation spectroscopy (FCS), yet the discussion can be extended to other single molecule detection methods.


http://www.mdpi.com/1422-0067/11/1/206/ag

Assistant Professor position in Marseille : nanophotonics & biophotonics

5 Février 2010 , Rédigé par JW Publié dans #Nanophotonics pick

The Fresnel Institute at the University of Marseilles (http://www.fresnel.fr), a leading laboratory in the field of Optics, Electromagnetism and Image Processing invites applications for an Associate Professor level position in the field of Biophotonics.


Outstanding candidates with demonstrated excellence in basic research in linear and nonlinear optical microscopy will have high priority. Expertise in nanoparticles fabrication and/or bio-labelling, optical field enhancement with nanostructure for bio-detection will be appreciated. Responsibilities will include conducting basic laboratory research in the Mosaic group http://www.fresnel.fr/mosaic) together with teaching (in French) at undergraduate and graduate levels at the University of Marseilles (Université de Provence) .

 

More information following this link.

 

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Latest paper: optical fibers to replace microscopes for single molecule fluorescence detection

5 Février 2010 , Rédigé par JW Publié dans #Recent research work

Intensity is not enough. Many techniques in optical microscopy take advantage of analysis methods based on single molecule detection events. These measurements provide access to a wide variety of data such as local concentration, structure or mobility of molecules. However, single molecule detection is a challenging task, which requires complex microscope apparatus and is very difficult to take out of the lab.


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A mobile endoscope to observe single molecules.

On collaboration with Bordeaux I University (France), my team has recently demonstrated the possibility to detect single fluorescent molecules with an optical fiber. The original system contains a glass microbead at the end of the optical fiber which works as a tiny lens to focus light. The fiber-microbead ensemble is also used to collect the low amount of light emitted by the individual molecules. That way, the bulky microscope is replaced by a remote fiber sensor connected to a miniaturized USB-connected device. This patented technique opens biomedicine and environment monitoring to single molecule analysis.

 

Reference

H. Aouani, F. Deiss, J. Wenger, P. Ferrand, N. Sojic, H. Rigneault, "Optical-fiber-microsphere for remote fluorescence correlation spectroscopy", Optics Express 17, 18912-18919 (2009)
Free download here
FiberFCS FDTD