Schrodinger’s cat is a Gedankenexperiment in quantum physics, in which an atomic decay triggers the death of the cat. Because quantum physics allow atoms to remain in superpositions of states, the classical cat would then be simultaneously dead and alive. By analogy, a ‘cat’ state of freely propagating light can be defined as a quantum superposition of well separated quasiclassical states—it is a classical light wave that simultaneously possesses two opposite phases. Such states play an important role in fundamental tests of quantum theory and in many quantum information processing tasks, including quantum computation, quantum teleportation and precision measurements. Recently, optical Schrodinger ‘kittens’ were prepared; however, they are too small for most of the aforementioned applications and increasing their size is experimentally challenging. Here we demonstrate, theoretically and experimentally, a protocol that allows the generation of arbitrarily large squeezed Schrodinger cat states, using homodyne detection and photon number states as resources. We implemented this protocol with light pulses containing two photons, producing a squeezed Schro¨dinger cat state with a negative Wigner function. This state clearly exhibits several quantum phase-space interference fringes between the ‘dead’ and ‘alive’ components, and is large enough to become useful for quantum information processing and experimental tests of quantum theory.

Current single-molecule detection techniques require labeling the target molecule. We report a highly specific and sensitive optical sensor based on an ultrahigh quality (Q) factor (Q > 1e8) whispering-gallery microcavity. The silica surface is functionalized to bind the target molecule; binding is detected by a resonant wavelength shift. Single-molecule detection is confirmed by observation of single-molecule binding events that shift the resonant frequency, as well as by the statistics for these shifts over many binding events. These shifts result from a thermo-optic mechanism. Additionally, label-free, single-molecule detection of interleukin-2 was demonstrated in serum. These experiments demonstrate a dynamic range of 1e12 in concentration, establishing the microcavity as a sensitive and versatile detector.

Because of their unique optical properties, the use of plasmons is getting more and more important for biological and medical research. These applications include the use of surface plasmon resonance (SPR) to measure bioaffinity reactions, tailoring fluorescence properties and the use of metal colloids as new light-scattering probes fro imaging or phototherapy. 

The goal of this workshop is to provide an interdisciplinary forum for state-of-the-art methods and instrumentation related the new research area of plasmonics and related nanosystems and their applications in biology and medicine. A poster session will complete the lectures and allows everyone to exchange their ideas on plasmonic.