Top articles
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Upcoming conferences 2018: the Bio-is-Nano Tour
Book your seats for the upcoming shows: - Ircelyon scientific day, Lyon, January 29 - Fluorescence markers for advanced microscopy, Les Houches, March 18-23 - Gold 2018 international conference, Paris, July 15-18 - NFO-15 international conference of Near-field...
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Stéphanie and Jérome awarded with Instrumentation prize 2017
The Instrumentation Prize from the Chemical Physics / Physical Chemistry division of the French Chemical and Physical Societies acknowledges the development of a new technology for chemical detection. This year, the prize has been awarded to Stéphanie...
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Book chapter: fluorescence spectroscopy enhancement on photonic nanoantennas
I have recently released a brief introduction to the key concepts for understanding the phenomenon of fluorescence enhancement with optical nanostructures. This document should be a chapter of a book “Plasmonics in Chemistry and Biology” edited by Nordin...
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Recent publication: nanoantenna FCS to probe biomembranes
Understanding the nanoscale organization of the cell membrane is a topic of high current interest. However, conventional optical microscopes fail to provide the combination of high spatial and temporal resolutions needed. We have recently introduced optical...
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New paper: High-resolution multimodal flexible coherent Raman endoscope
Coherent Raman imaging is a label free technique featuring chemical sensitivity that has a great potential for direct cancer cell imaging. However high-resolution, high contrast coherent Raman images have so far been restricted to table-top microscopes....
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Latest article: green laser excitation can quench red dyes fluorescence
A wide range of single molecule fluorescence techniques involve the use of multi-color laser excitation, such as PIE-FRET, ALEX-FRET and FCCS. However, the influence of these various laser excitations is very often overlooked. What is the influence of...
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Raju Regmi is awarded the Aix Marseille University PhD thesis prize for 2017
Raju just got awarded with the "Prix de Thèse" of Aix Marseille University which acknowledges the best thesis defended at the university during the past year. The prize comes with a 1000€ award (always welcome ;o) Before that, Raju also received the prize...
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Microwave FRET imaging inside a photonic cavity
Light can be trapped inside a cavity made by two mirrors, thus concentrating the light intensity and enhancing interactions between light and matter. Among the different applications of these photonic cavities, much attention is now focused on their ability...
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France Bioimaging Open Day
On May 25th, we will present several demonstration experiments about manipulating light with optics. This year, we have a special celebration with the bicentenary of Augustin Fresnel's theory of diffraction, and we will be redoing the historical Fresnel...
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Temperature Measurement in Plasmonic Nanoapertures Used for Optical Trapping
Optical absorption in plasmonic structures lead to a local temperature increase. It was long assumed that in the case of nanoapertures, the extended metal layer was acting as an efficient heat sink to mitigate the warming. However, the reality is that...
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Extending Single-Molecule Förster Resonance Energy Transfer (FRET) Range beyond 10 Nanometers in Zero-Mode Waveguides
Förster resonance energy transfer (FRET) is widely used as a molecular ruler to monitor biomolecular conformations and interactions dynamics. However, an intrinsic limitation in FRET is that the signal decreases very rapidly with the dye to dye distance,...
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Preventing Aluminum Photocorrosion for Ultraviolet Plasmonics
Ultraviolet plasmonics is a burgeoning scientific field where the strong molecular absorption bands in the UV range are combined with the intense electromagnetic fields of plasmonic nanostructures. This powerful combination is highly promising to promote...
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Deep UV plasmonic enhancement of single protein autofluorescence in zero-mode waveguides
Detecting proteins in the UV range is appealing to take advantage of their natural tryptophan fluorescence and rule out all the issues related with external fluorescence labelling. However, proteins feature a much lower fluorescence brightness than conventional...
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Nanophotonics and Micro/Nano Optics International Conference 2020
Chaired by Patrice Genevet and co-chaired by Jerome Wenger, the Nanophotonics and Micro/Nano Optics International Conference 2020 is proudly featuring an outstanding list of 12 outstanding invited speakers. The conference attendance is limited to 250...
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Reproducing Fresnel-Arago experiment to illustrate the main concepts of physical optics
Following our video series on Fresnel-Arago experiment's modern version, we have relased an arXiv paper describing how to mount the setup, prepare the sample and perform a selection of experiments. Many concepts of physical optics can be visually illustrated...
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Adhesion Layer Influence on Controlling the Local Temperature in Plasmonic Gold Nanoholes
Adhesion layers of chromium or titanium are widely used in plasmonics to ensure a proper adhesion between a gold film and a glass substrate. However, very little is known about their influence on the thermal response. As a result, the adhesion layer is...
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No virus will stop the ERC
Organic chemistry is gaining an increasing interest in the optics lab these days. According to WHO, here is a simple hanrub sanitizer recipe: For a 1L solution, mix 833mL ethanol 96%, 4.2mL hydrogen peroxide 30%, 1.5mL glycerol and 161mL pure water. Shake...
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[ArmadaCrew] Emergency evacuation order
[Arcadia - Queen Emeraldas Revenge - Shadow Princess - Ebbesen's blade crew member] Immediate evacuation order by emergency exits. This is not an exercise. Retreat with calm and discipline. ---- Gentlemen, it's been an honour and a privilege to be your...
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Surface passivation of zero-mode waveguide nanostructures: benchmarking protocols and fluorescent labels
Zero-mode waveguide nanoapertures receive a large interest owing to their ability to confine light at the nanoscale and improve the detection of single fluorescent molecules. However, unwanted adhesion of the targeted molecules onto the metal surface...
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Ultraviolet Photostability Improvement for Autofluorescence Correlation Spectroscopy on Label-Free Proteins
The natural autofluorescence of proteins in the UV is appealing to get the detailed information from single molecule data without requiring a potentially disturbing external fluorescent label. However, proteins feature significantly lower autofluorescence...
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Long-Range Single-Molecule Förster Resonance Energy Transfer between Alexa Dyes in Zero-Mode Waveguides
Förster resonance energy transfer (FRET) is widely used as a molecular ruler to monitor biomolecular conformations and interactions dynamics, but FRET is generally limited to distances below 10 nm. Last year, we showed that zero-mode waveguides (ZMW)...
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The Armada is on fly again
Soon our flag will flutter again over the Sea of Nanos. Wed. May 13th 2pm CEST: Ebbesen's Blade is on fly again. Thu. May 14th 3pm CEST: Shadow Princess took off and is fully operational. Fri. May 15th 12am CEST: Arcadia hashin! Thu. May 28th 4pm CEST:...
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Nanoscale control of smFRET by a scanning photonic nanoantenna
Förster Resonance Energy Transfer (FRET) governs energy exchanges at the nanoscale and can be used to accurately measure intra- and inter-molecular distances with sub-nm accuracy. While photonic nanoantennas have been shown to modify FRET, most of the...
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Zero-mode waveguides can be made better with optimized rectangle shapes
Zero-mode waveguide metal nanoapertures are receiving a large interest owing to their ability to confine light at the nanoscale and enhance the fluorescence emission from single molecules. However, the interest for more advanced geometries beyond the...
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Reproducing the Fresnel-Arago experiment to illustrate physical optics
Now published in Photoniques , the journal of the French Optical Society, international (english) edition: Is there a bright spot in the shadow of an opaque disk? Nearly 200 years ago, Augustin Fresnel and François Arago’s remarkable answer to this question...
