Jerome Wenger NanoBioPhotonics

Super-resolution microscopy techniques such as PALM/STORM/STED are revolutionizing optical imaging. While diffraction is no longer a limit, another technical barrier arises driven by the need to compensate for mechanical and thermal drifts at the nanoscale. In a recent article published in Nature Communications, we introduce a novel approach to enhance the image quality in dSTORM microscopy by 3D super-localization of nanoparticles with unprecedented nanometer accuracy.

Significance:

- We show how to exploit the phase response of nanoparticles to recover their 3D position with sub-nanometer accuracy, two orders of magnitude below the diffraction limit, even with large and unknown drifts of several microns.

- The platform uses a commercial wavefront sensing camera to realize highly efficient 3D stabilization and resolution improvement for super-resolution microscopes.

This work provides a leap towards the design of optical super-resolution microscopes with nanometer resolutions, reaching the dream of biological imaging at the molecular scale.

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Had a verynice interaction with the audience this morning at the European Summer School on the Physics of Light in Strasbourg.

My slides can be found here: Concentrating Light at the Nanoscale, Plasmonics and Nano-Optics

From the official terms: "the Fabry - de Gramont award of the French Optical Society acknowledges a young researcher (under 40) internationally recognized and whose research has been noted for its quality and originality". It's a great honour to become member of a distinguished list of laureates.

Featuring some colleagues of Institut Fresnel \ Mosaic