Planar plasmonic antennas resolve transient nanoscopic phase separation in biological lipid membranes
Nanoscopic domains (also known as lipid rafts) in living cell membranes have been postulated to play major roles in regulating a large variety of biological functions. However, the underlying basis for their formation remains under heavy debate because their typical sizes and characteristic times are below the resolution of standard microscopes.
In a recent ACS Nano publication entitled Transient Nanoscopic Phase Separation in Biological Lipid Membranes Resolved by Planar Plasmonic Antennas, we report on the application of in-plane plasmonic antenna arrays with different nanogap sizes in combination with fluorescence correlation spectroscopy (FCS) to assess the dynamic nanoscale organization of mimetic biological membranes. Our approach takes advantage of the highly enhanced and confined excitation light provided by dimer nano-antennas together with their outstanding planarity to investigate membrane regions as small as 10 nm in size with microsecond time resolution.
- We show the existence of transient nanoscopic domains in both liquid-order and liquid-disorder phases of mimetic biological membranes, featuring characteristic sizes of 10 nm with residence times between 30 µs and 150 µs
- Our planar optical antenna methodology provides nanoscale observation areas with microsecond time resolution and full biocompatibility. This constitutes a significant step forward in our ability to address native biological membranes with unprecedented spatiotemporal resolution.
CORDIS (Community Research and Development Information Service) is a key instrument for effective dissemination and exploitation of EU-funded research results. Our ExtendFRET project was recently selected by the CORDIS Editorial Team to be written about in a "Results in Brief" article, given the exciting results and promising aspects of the project.
Submissions and registrations for the 4th Summer School On Plasmonics (SSOP4) are now open. The school will be held on September 3-8, 2017, in Porquerolles, one of the most beautiful island of the Mediterranean sea. Please find more information at http:www.fresnel.fr/ssop4/
Lectures and tutorials presented by international specialists on plasmonics will cover the following topics:
- Resonant Light scattering by nanoparticles
- Interaction forces between plasmonic nanoparticles
- Hyperbolic Metamaterials, Metasurfaces
- Purcell factor, single photon sources, FRET, fluorescence, strong coupling
- NSOM microscopy
- Spectral filters
- DNA nanotechnologies, plasmonic sensors
- Cathodoluminescence spectroscopy
- Nanofabrication technologies,Ellipsometry and polarimetry
Key arguments for your supervisor: rare advanced lectures on modern plasmonics + excellent quality of invited lecturers + excellent value for the money, the registration fee covers all accomodation & food expenses.
From the ICFO news: The European Commission has a very clear strategy for the effective dissemination and exploitation of EU-funded research results in which CORDIS (Community Research and Development Information Service) plays a primary role. The NANO-VISTA project, coordinated by ICREA Professor at ICFO Dr. Maria Garcia-Parajo, was recently highlighted by the European Commission’s Project Officer and selected by the CORDIS Editorial Team to be written about in a "Results in Brief" article, given the exciting results and promising aspects of the project.